Literature Review

[KARYA 1]

LOMBA : Warmadewa Aesculapius Scientific Competition 2017
PRESTASI : Juara 1

Vaksin Pneumokokus Berbasis Protein (Pneumococcal Protein Vaccine: PPrV) Model Trivalent dengan Komposisi Antigen Protein PhtD, PcpA, dan PlyD1 dengan Adjuvan Aluminium dengan Metode Administrasi Secara Intranasal Sebagai Metode Vaksinasi Terbaru untuk Pencegahan Pneumonia pada Balita

Eddy Zulfikar1, Farhan Naufal Arif1, Imam Hermansyah1,

Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Hasanuddin, Makassar

Abstrak

Latar Belakang: Pneumonia merupakan penyakit infeksi pernapasan akut yang menyerang alveoli paru-paru. Menurut WHO, Pneumonia merupakan penyebab utama kematian pada balita di seluruh dunia. Saat ini, vaksin pneumokokus konjugat (Pneumococcal Conjugate Vaccine: PCV) dijadikan sebagai vaksin utama yang direkomendasikan untuk mencegah pneumonia pada balita. Namun, nyatanya PCV masih memiliki banyak keterbatasan dikarenakan komposisi serotype-nya. Oleh karena itu, dibutuhkan inovasi terbaru terkait dengan vaksin beserta metode yang lebih efektif dalam program vaksinasi pneumonia pada balita. Tujuan: Untuk mengetahui jenis vaksin beserta metode administrasi yang efektif untuk mencegah pneumonia pada balita. Metode: Literature review ini disusun berdasarkan metode studi pustaka dengan cara mengumpulkan berbagai referensi yang valid mengenai efektivitas vaksin pneumokokus berbasis protein (PPrV) model trivalent (PhtD, PcpA, dan PlyD1) dengan adjuvan aluminium dengan metode administrasi secara intranasal sebagai metode vaksinasi terbaru untuk mencegah pneumonia pada balita. Hasil: Pada bayi (42-49 hari) maupun batita (12-13 bulan), vaksinasi dengan PPrV mampu meningkatkan konsentrasi antibodi terhadap ketiga antigen protein yang diujikan. Untuk respon antibodi yang maksimal, pada bayi diperlukan adanya penambahan adjuvan aluminium dengan tiga kali tahapan vaksinasi menggunakan formula antigen protein sebesar 25μg atau 50μg. Sedangkan untuk batita, peningkatan antibodi yang signifikan dapat diperoleh melalui vaksinasi dosis tunggal dengan formula 50 μg dengan adjuvan yang sama. Administrasi PPrV secara intranasal dipilih karena mampu menginduksi imunitas mukosa dengan respon memori sel B dan sel T dalam jangka waktu yang lebih lama, serta meminimalisir efek samping dan rasa sakit. Kesimpulan: Penggunaan PPrV model trivalent (PhtD, PcpA, dan PlyD1) dengan adjuvan aluminium dengan metode administrasi secara intranasal, mampu meningkatkan konsentrasi antibodi bayi maupun batita sebanyak dua hingga empat kali lipat, mampu menginduksi sistem imun mukosa dengan respon sel memori yang lebih lama, juga minim efek samping dan rasa sakit saat vaksinasi.

Kata kunci: administrasi intranasal, aluminium, balita, pneumonia, PPrV, trivalent

[KARYA 2]


LOMBA : Medical Sebelas Maret Scientific Competition 2017
PRESTASI : Juara 3

Potensi Glucagon Like Peptide-1 (GLP-1) Receptor Agonist Exendin4 Berbasis Polimer Polietilen Glikol (PEG) dengan Adminstrasi Secara Transdermal Tip Loaded Microneedle Array sebagai Modalitas Terapi Post Infark Miokard

Ummu Aiman1, Ayu Andini1, A. Dwiki Cahyadi1  1 Program Pendidikan Dokter , Fakultas Kedokteran, Universitas Hasanuddin, Makassar

ABSTRACT

Myocardial infarction is still a global heart health problem with high prevalence. The presence of impaired blood flow and oxygen supply to the heart muscle causes cell death or necrosis. Post myocardial infarction needs attention by looking at the frequent complications of heart failure. According to previous research GLP-1R (Glucagon Like Peptide) Receptor Agonist Exendin-4 is one hyperglycemia drug that has good affinity in protecting post cardiac myocardial infarction. With the addition of polymer polyethylene glycol (PEG) to exendin-4 is expected to increase the absorption of exendin-4 in the body so that it can be a post-myocardial therapy modality with transdermal drug delivery formulation of tip-loaded microneedle arrays with  penetrating through skin properties and are practical in their use. This writing aims to determine the activity of cardioprotective PEG-Exendin-4 which is formulated in  tip loaded microneedle Array drug delivery system. Writing methods by taking literature such as journals and books published in the last 10 years related to Myocardial Infarction, Exendin-4, Polyethylene glycol (PEG), and microneedle Array. The results show that PGE-Exendin-4 has a high affinity for GLP-1R and has the effect of enhancing the contractile function of the heart, decreasing fibroblasts and ventricular hypertrophy in preventing vectoric remodeling as well as initiating angiogenesis. Needs further research to find out the exact dose of PGE-Exendin4.

Keywords: Myocard infarct, PGE Exendin-4, Cardioprotective, tip loaded microneedle Array

 

[KARYA 3]


LOMBA : Temu Ilmiah Nasional 2017 University of Muhammadiyah Jakarta
PRESTASI : Juara 2

“Thyrotropin Releasing Hormone (TRH) and Ketamin filled Anti-suicidal Nasal Spray as an Immediate Management In Acute Suicidal State”

Siti Anissa Safira, Dr. dr. Masita Fujiko, SpOG

Siti Anissa Safira, (081340038333, Jl. Buakana C12 Makassar, stanissafira@gmail.com)

 

Abstract

Suicide is one of the leading causes of death globally for all ages, and every year nearly one million people die from it. Every suicide is a tragedy that affects families, communities and entire countries and has long-lasting effects on the people left behind. The only management in suicide is to prevent it from happening by controlling the suicide ideation and behavior before one lead to successfully attempting suicide. Currently, suicide ideation and behavioral management focused around psychotherapies, psychopharmacology, and even electro convulsion therapy (ECT).  These managements is not well applicable in people with acute state of suicidal. Pharmacological strategies that have rapid action of antidepressant effects within hours would therefore have an enormous impact on public health. Recently a lot of research shows the potency of thyrotrophin releasing hormone (TRH) as a rapid acting anti-suicidal. TRH act by attaching to thyrotropin receptors in the brain and inhibit the suicidal behavior. The rapidity of ketamine’s antidepressant effects has sparked interest in its potential as an anti-suicide treatment and its action in increasing synthesis and release of TRH will make TRH and ketamine a great beneficial combination. Intranasal administration (nasal spray) provide a great access to pass through blood-brain barrier and to the brain. Therefore the combination of TRH and ketamine prepared in an easily used from, which is intranasal spray, is predicted to achieve quick anti-suicidal effect and is hoped to serve an immediate management as prevention in acute suicidal state.

Keywords : nasal spray, ketamine, suicide, thyrotropin-releasing hormone (TRH)